Abstract
Myocardial injury is a serious complication of sepsis. The present study aimed to identify potential biomarkers of sepsis-induced myocardial injury. Differentially expressed genes (DEGs) in patients and mice with sepsis-induced myocardial injury were identified via bioinformatic analysis. The identified DEG was tested in elderly patients with sepsis-induced myocardial injury. We identified 19 co-expressed DEGs. The most significant DEG was eotaxin-1/CCL11. We enrolled 25 controls without infections and 28 patients with sepsis-induced myocardial injury. Six of patients died within 30 days. Circulating eotaxin-1/CCL11 levels were significantly higher in patients with sepsis-induced myocardial injury than controls and were higher in non-survivors than survivors (both P < 0.01). Eotaxin-1/CCL11 was positively correlated with troponin I (r=0.48, P=0.01), B-type natriuretic peptide (BNP, r=0.44, P=0.02), and white blood cell (WBC) count (r=0.41, P=0.03). For the prediction of 30-day mortality, eotaxin-1/CCL11 had the greatest discriminatory ability (AUC 0.97) compared with troponin I (AUC 0.89), BNP (AUC 0.80), and WBC count (AUC 0.86). Taken together, eotaxin-1/CCL11 was upregulated in sepsis-injured myocardium and circulating eotaxin-1/CCL11 was a biomarker for predicting severity and mortality of elderly patients with sepsis-induced myocardial injury. These results suggest that eotaxin-1/CCL11 may become a useful biomarkers and potential therapeutic target for sepsis-induced myocardial injury.
Highlights
Sepsis is considered as a life-threatening condition caused by dysregulated, inappropriate host response to an infection, such as pneumonia
We found 133 differentially expressed genes (DEGs) in human heart specimens of sepsis-induced myocardial injury patients compared with nonfailing human heart specimens, including 39 down-regulated genes and 94 up-regulated genes
We confirmed the role of eotaxin-1/CCL11 in sepsis-induced myocardial injury using the blood samples from elderly patients with sepsis-induced myocardial injury
Summary
Sepsis is considered as a life-threatening condition caused by dysregulated, inappropriate host response to an infection, such as pneumonia. In elderly patients, sepsis remains a leading cause of death worldwide [1]. Myocardial dysfunction or cardiomyocyte injury frequently occurs in patients with sepsis, which is known as septic cardiomyopathy, an emerging challenge in clinical practice [2, 3]. Sepsis-induced myocardial injury, characterized by elevation in biomarkers of cardiomyocyte injury, is an important contributor to multiorgan dysfunction in sepsis and associated with increased morbidity and mortality [4,5,6]. Treatment of sepsis-induced myocardial injury mainly focuses on treating the underlying infection and sepsis and providing nonspecific supportive care [5]. There is no specific therapy for sepsis-induced myocardial injury owing to www.aging-us.com incomplete understanding of the underlying pathogenesis
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