Role of electrical activity during cortical interneuron development

Abstract

Event Abstract Back to Event Role of electrical activity during cortical interneuron development F. Alfonsi1* and N. Tekki-Kessaris1 1 WIBR/UCL, Department of Signal Processing, United Kingdom Electrical activity acts in synergy with genetic programs to regulate different aspects of neuronal development such as precursor proliferation, differentiation, and migration, as well as incorporation of neurons into functional circuits. In vitro studies have shown a role for Glutamate and GABA signals during cortical GABAergic interneuron migration. However, the requirement for these mechanisms in vivo is still unclear. In this study we examine the in vivo role of Glutamate signalling via NMDA receptors during cortical interneuron development. We use a conditional deletion approach where we examine either the cell autonomous effect of deleting NMDAR1 (NR1) in immature migrating interneurons, or the cell non-autonomous effect of disrupting NR1 in cortical pyramidal neurons. We find a requirement for NR1-mediated signals in both cortical interneurons as well as cortical pyramidal cells: deleting NR1 in either of these two populations has differential effects on cortical interneurons. Conference: EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Alfonsi F and Tekki-Kessaris N (2010). Role of electrical activity during cortical interneuron development. Conference Abstract: EMBO workshop: Gaba Signalling and Brain Networks . doi: 10.3389/conf.fnins.2010.15.00001 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Jun 2010; Published Online: 22 Jun 2010. * Correspondence: F. Alfonsi, WIBR/UCL, Department of Signal Processing, London, United Kingdom, f.alfonsi@wibr.ucl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers F. Alfonsi N. Tekki-Kessaris Google F. Alfonsi N. Tekki-Kessaris Google Scholar F. Alfonsi N. Tekki-Kessaris PubMed F. Alfonsi N. Tekki-Kessaris Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.