Abstract
During early embryonic development,these epithelial cells of cardiac atrioventricular and outflow tract undergo an epithelial-mesenchymal transformation to become mesenchymal cells that invade cardiac jelly,forming endocardial cushion.Epidermal growth factor family plays an important role in regulating epithelial-mesenchymal transformation.The family is composed of multiple ligands and four tyrosine kinase receptors ( ErbB),among which ErbB2 and ErbB3 are necessary for normal development of endocardial cushion.In addition,other receptors and ligands also play important roles in heart development.This review discusses the role of receptors and ligands of the EGF family in heart endocardial cushion development. Key words: Endocardial cushion; Epithelial-m esenchymal transformation; Epidermal growth factor family
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