Abstract
Epidermal growth factor(EGF) family and EGF reeeptor(EGFR) play pivotal roles in cell proliferation, tissue repair, and normal cellular homeostasis. Main pathologic feature of idiopathic pulmonary fibrosis is proliferation of fibroblasts stimulated with various growth factors. EGF and EGFR stimulate fibroblast proliferation and play an important role in pathogenesis of pulmonary fibrosis. Molecular targeted drugs of EGFR tyrosine kinase inhibitors (EGFR-TKI) have been attracting a great deal of attention as novel cancer therapies. To investigate the effect of EGFR-TKI on lung fibrosis is worthy of more concerns. Key words: Epidermal growth factor; Pulmonary fibrosis
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