Abstract
This chapter discusses the role of dopamine and norepinephrine in the chemistry of reward. Central catecholamine systems are important substrates of intracranialself-stimulation (ICS). Drugs that deplete catecholamine stores (for example, reserpine, tetrabenazine) inhibit the synthesis of catecholamines (for example, α-methyltyrosine, disulfiram) block postsynaptic catecholamine receptor sites (for example, pimozide, haloperidol, chlorpromazine) or destroy central catecholaminergic neurons (for example, 6-hydroxydopamine) decrease ICS. On the other hand, agents that increase the synaptic release and block re-uptake of catecholamines or increase brain CA levels by inhibiting their catabolism can increase ICS. There is a possibilityof discriminating between the noradrenergic and dopaminergic mechanisms that mediate the behavioral effects of amphetamine by examining the effects of the d- and /-isomers on these behaviors.
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