Abstract
Aim: To evaluate the efficacy and diagnostic accuracy of cytological techniques in evaluation of noninfectious vesiculobulloous lesions of skin. Materials and methods: Tzanck smear prepared from vesiculobullous lesions. Giemsa stainining of cytology smears. Biopsy of lesions where possible. Result: 22 patients (indoor/outdoor) with vesiculobullous skin lesions were subjected to cytological examination and biopsy. Twenty two cases of vesiculobullous lesions were comprised of 12 cases (54.54%) of bullous pemphigoid, 7 cases (12.96%) of pemphigus vulgaris, two cases of linear IgA bullous dermatosis (9.09%) and one case of pemphigus foliaceus (1.85%). Sensitivity, specificity and diagnostic accuracy of tzanck smear for diagnosing vesiculobullous lesions were 100%, 100% and 100% respectively Conclusion: Cytological examination is a very simple and useful modality, requires minimum equipments and can be performed in outpatient clinic. The procedure is safe, free from complications and is well tolerated by patients.
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