Abstract
This study was performed to examine the role of the carotid bodies (CB) in glucoregulation during prolonged exercise in humans. Six healthy males (35 ± 5 yrs) completed two 120 minute bouts of cycling exercise (65% VO2max), during a dopamine infusion (D; 2 μg/kg/min) to acutely inactivate the CB, or a placebo, saline infusion (P). Arterial blood was drawn for glucose and counter‐regulatory hormones at baseline and during exercise (60–80: 60–80 minute mean; EE: end exercise). All variables at baseline were similar between conditions. Glucose concentration decreased throughout exercise and was similar between trials (60–80: 90 ± 7 vs. 98 ± 14; EE: 75 ± 12 vs. 80 ± 10 mg/dl; D vs. P respectively). However, when compared to baseline values, EE glucose had a greater decrease in 4 subjects during D, whereas 2 subjects had a greater attenuation during P. Glucagon was similar at 60–80 (108 ± 42 vs. 84 ± 40 pg/ml; D vs. P respectively), but was greater at EE in D than P (204 ± 104 vs. 136 ± 70 pg/ml). Cortisol (60–80: 13 ± 5 vs. 16 ± 4; EE: 22 ± 3 vs. 20 ± 7 μg/dl; D vs. P respectively) and growth hormone (60–80: 13 ± 3 vs. 12 ± 3; EE: 12 ± 4 vs. 10 ± 4 ng/ml; D vs. P respectively) concentrations were not different between conditions. Our preliminary results indicate that blood glucose during exercise with CB desensitization varies between subjects, and that the CB might contribute to blood glucose regulation during exercise. Funding: NIH R01DK090541
Published Version
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