Role of carbohydrate antigen 125 on the diagnosis and prognosis of acute heart failure

Abstract

Objective To investigate the value of serum carbohydrate antigen 125(CA125)in the diagnosis of acute heart failure and its clinical prognosis. Methods From August 2015 to August 2016, 173 patients with acute heart failure in the Department of Cardiology of Jintan Hospital Affiliated to Jiangsu University and Jiangsu Province Subei People′s Hospital were enrolled in this study.According to the New York Heart Association(NYHA)classification, they were divided into NYHA class Ⅲ or class Ⅳ group.Fifty healthy subjects were selected as the control group as well.The blood levels of N-terminal pro B-type natriuretic peptide(NT-proBNP), high-sensitivity C-reactive protein(hs-CRP)and CA125 in each group were measured and compared, correlation analysis with parameters of echocardiography and the mortality rate of patients in each group were observed. Results Compared with the control group, the levels of BNP, hs-CRP and CA125 were significantly increased in patients with acute heart failure, and gradually increased with the increase of NYHA heart function classification.The difference was statistically significant(P<0.01). CA125 and hs-CRP levels and left ventricular end diastolic diameter(LVEDD)were positively correlated with NT-proBNP(r=0.401, 0.316, 0.445, all P<0.01), left ventricular ejection fraction(LVEF)was negatively correlated with NT-proBNP(r=-0.642, P<0.01). Conclusions CA125 levels is elevated in patients with acute heart failure and can be used as an important index in the diagnosis of heart failure and for prediction of the clinical prognosis. Key words: Serum carbohydrate antigen 125; Acute heart failure; Left ventricular ejection fraction; Prognosis