Abstract
Calponin is a family of actin filament-associated regulatory proteins and functions via inhibiting actin-activated myosin ATPase activity. Among three calponin isoforms in vertebrates, calponin 2 encoded by Cnn2 gene expresses in smooth muscles and non-muscle cells such as monocytes/macrophages, endothelial cells, epithelial cells, fibroblasts, myoblasts, and lung alveolar cells. Our group previously reported that calponin 2 regulates the rate of cell proliferation and migration by stabilizing the actin cytoskeleton.
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