Abstract
Background: Type 1 diabetes mellitus (DM) results from a cell-mediated autoimmune attack against pancreatic beta cells and characterized by severe damage to many tissues. Several in vitro studies have shown that bone marrow derived stem cells could be reprogrammed to become functionally insulin producing cells under certain culture conditions. Purpose: The aim of this study is to demonstrate that bone marrow derived mesenchymal stem cells (MSCs) can be induced to differentiate into insulin producing cells (IPCs) under suitable culture condition and to assess the ability of these differentiated cells to correct the functional defect in insulin secretion. Materials and methods: This study was done on 9 dogs, one as a negative control and 8 were induced to be diabetic. MSCs were isolated from bone marrow and induced to differentiate into IPCs. Two diabetic dogs received undifferentiated MSCs transplant, while another 2 diabetic dogs received differentiated MSCs and 1 diabetic dog remained as a positive control. Results: The diabetic dogs that received undifferentiated MSCs showed no improvement in FBG level during the observation period while the diabetic dogs that received differentiated MSCs showed improvement in FBG on day 6 after transplantation. Conclusion: This study suggests that bone marrow MSCs can be differentiate into IPCs that can improve FBG levels in diabetics.
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