Abstract
Objective: study was conducted to assess role of beta-2 microglobulin in renal dysfunction of Neonates with Birth Asphyxia. Methods: Study is a Case control studyand a total of 140 babies were selected for study group as cases of birth asphyxia and 70 normal term babies were selected as control group randomly. Urine samples were taken on day 1, 3 and day 7 in all the babies and beta 2 microglobulin (B2M) values were estimated in all the babies by ELISA method from urine samples. Results: The mean value of beta 2 microglobulin ( B2M) in neonates with birth asphyxia were 10.53 + 6.03, 8.25 + 3.56, 6.25 + 2.72 mg / L and in neonates of control group were 1.61 + 1.01, 1.51 + 1.04 and 1.54 + 1.03 mg / L on day 1, 3 and 7. The p-value for these two groups was < 0.001, which is highly significant. Conclusion: beta 2 microglobulin (B2M) is a sensitive indicator for renal dysfunction. It can even detect subclinical renal impairments in neonates with birth asphyxia which are usually missed by standard renal function tests. It can also be used as early marker or screening test for renal impairments.
Highlights
Beta-2 microglobulins (B2M) are present in most of human cells which is a small polypeptide and is present in all body fluids
In the present study 140 cases were taken as study group and 70 normal babies as control group
From above table it is clear that the mean weight of study group was 2780 + 350 grams and mean weight of control group was 2788 + 334 grams
Summary
Beta-2 microglobulins (B2M) are present in most of human cells which is a small polypeptide and is present in all body fluids. It is filtered freely by glomeruli and reabsorbed almost completely (99.9%) by proximal convoluted tubules in normal neonates. Increased excretion of urinary B2M, indicates renal tubular dysfunction [1,2,3]. Glomerular B2M is a very less used metabolite. It can be used in assessing renal function, especially in babies suspected of renal tubular or interstitial disease. There is tubular balance for Manuscript received:04th Dec 2015 Reviewed: 15th Dec 2015 Author Corrected; 29th Dec 2015 Accepted for Publication: 09th Jan 2016
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