Abstract
Tuberculosis is caused by Mycobacterium tuberculosis, one of the most successful and deadliest human pathogen. Aminoglycosides resistance leads to emergence of extremely drug resistant strains of M. tuberculosis. Iron is crucial for the biological functions of the cells. Iron assimilation, storage and their utilization is not only involved in pathogenesis but also in emergence of drug resistance strains. We previously reported that iron storing proteins (bacterioferritin and ferritin) were found to be overexpressed in aminoglycosides resistant isolates. In this study we performed the STRING analysis of bacterioferritin & ferritin proteins and predicted their interactive partners [ferrochelatase (hemH), Rv1877 (hypothetical protein/probable conserved integral membrane protein), uroporphyrinogen decarboxylase (hemE) trigger factor (tig), transcriptional regulatory protein (MT3948), hypothetical protein (MT1928), glnA3 (glutamine synthetase), molecular chaperone GroEL (groEL1 & hsp65), and hypothetical protein (MT3947)]. We suggested that interactive partners of bacterioferritin and ferritin are directly or indirectly involved in M. tuberculosis growth, homeostasis, iron assimilation, virulence, resistance, and stresses.
Highlights
Mycobacterium tuberculosis is the causing factor of tuberculosis (TB) etiology and remains one of the top 10 causes of death worldwide in 2015
Proteins engage in iron storage, assimilation, regulation, uptake and their utilization could be involved in M. tuberculosis pathobiology, growth, virulence and latency and in aminoglycosides drug resistance and might be potential anti-mycobacterial drug target against the drug resistant tuberculosis (Reddy et al, 2012; Kumar et al, 2013; Sharma et al, 2015b, 2016a; Khare et al, 2017)
Pandey and Rodriguez suggested that ferritin is mandatory to maintain iron homeostasis in M. tuberculosis and ferritin deficient bacilli are more susceptible to killing by antibiotics (Pandey and Rodriguez, 2012)
Summary
Mycobacterium tuberculosis is the causing factor of tuberculosis (TB) etiology and remains one of the top 10 causes of death worldwide in 2015. We emphasized on the M. tuberculosis iron storage proteins (bacterioferritin and ferritin) and their interactive protein partners which might be involved in pathogenesis, virulence and drug resistance.
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