Abstract
Multiple Sclerosis is a multifactorial disease characterized by demyelination and inflammation of the central nervous system. Accumulating data indicate that changes in the balance of antioxidants and oxidants contributed to the MS pathophysiology. The aim of the study to obtain a better understanding of the oxidative stress process to select a proper method of predicting the prognosis of the relapsing-remitting MS (RRMS). Serum of 97 patients (30 newly diagnosed RRMS patients and 67 RRMS patients underwent treatment) and 35 healthy individuals as control group. Serum levels of 25-hydroxycholecalciferol [25(OH)D3], vitamin E, vitamin C, malondialdehyde, protein carbonyl, and 8-hydroxydeoxyguanosine. There was a negative correlation between MDA and antioxidant (vitamin C and vitamin E), whereas a positive correlation between MDA and other oxidative stress (PC and 8-OHdG). Receiver operator characteristic analysis showed that PC was an ideal marker while vitamin C, MDA, 8-OHdG were excellent markers. Our data showed that the above markers as a mean could be used to predict MS disease and the extent of its progression.
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