Role of Amyloid‐β in Alzheimer's Disease

Abstract

Irrespective of whether one comes from a diagnostic, a genetic or a pathologic perspective, amyloid-β is both at the forefront and in the centre of the minds of those involved in the study of Alzheimer's disease. The ‘Amyloid-β Cascade Hypothesis’ is the dominant theory touted currently as being responsible for pathogenesis of the disease. However, as with any theory, the role of amyloid-β is not without its detractors. To encapsulate the arguments from both sides in this issue of the International Journal of Experimental Pathology, we have been fortunate to garnish reviews from some of the foremost thought leaders in the field. It is, we hope, clearly evident from the scholarly contributions from these authors that this topic has attracted some of the most innovative of research groups internationally. Their work is much in demand, and therefore as editors, we are privileged that these investigators have agreed to participate in the special issue. We are also grateful to the Editor-in-Chief, Professor David Katz, for facilitating the opportunity to publish the series of papers in the International Journal of Experimental Pathology.