Abstract
Microglia in Alzheimer's Disease
Highlights
The first paper I would suggest the readers to read is R
Recent insights regarding molecular mechanisms that regulate the diverse microglia responses are summarized. The understanding of these molecular pathways would lead to targeted therapies aimed at modulating microlgial behavior toward neuroprotection, as exemplified by approaches targeting the microglial KCa3.1 potassium channel, scavenger receptors, or complements, for example
Mrak suggest that microglia actively influence the pattern of development of amyloid plaques as well as neuronal tangle formation in Alzheimer’s disease (AD) brains, rather than simple associations with these lesions
Summary
The first paper I would suggest the readers to read is R. A core theme of the articles presented in this special issue is the dichotomous role played by the microglia—the contextdependent neuroprotective and neurotoxic functions. E. Mrak suggest that microglia actively influence the pattern of development of amyloid plaques as well as neuronal tangle formation in AD brains, rather than simple associations with these lesions.
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