Role of AGTR1 gene polymorphism in progression and development of complications of atrial fibrillation in combination with hypertension disease

Abstract

Aim. To study the role of the rs5186 polymorphism of the AGTR1 gene in the progression and development of complications of atrial fibrillation in combination with hypertension.Methods. A prospective cohort study included 86 patients with paroxysmal and persistent AF and stage II hypertension, grade I–II hypertension, with Echocardiography signs of LVH, without significant comorbidity, without coronary artery disease. All patients were followed up for 12 months to assess the development of complications such as AF recurrence, cardioembolism, hospitalization and chronic heart failure (CHF). The mean age of the studied patients was 53.3 ± 7.1 years.Results. During the observation period, out of 86 patients, 16 people developed a recurrence of AF. Cases of cardioembolism were recorded in 17 people. Of the 86 observed patients, 43 were rehospitalized. When evaluating the association of the rs5186 polymorphism of the AGTR1 gene with the risk of readmission within a year, it was found that the CT genotype of the rs5186 polymorphism of the AGTR1 gene (RR = 2.28; p = 0.004) and the CC genotype (RR = 0.44; p = 0.005) significantly increase the risk of hospitalization. CHF was registered in 26 (30.2 %) patients out of 86 observed. Thus, the study of the role of the rs5186 polymorphism of the AGTR1 gene in the progression and development of complications of atrial fibrillation in combination with hypertension, according to the present study, does not make it possible to determine a significant predictor of AF progression, however, a predictor of the risk of hospitalization ACTR1/CT was identified (2.28 [1.30; 4.05], p < 0.004; 2.45 [1.33; 4.61], p < 0.004; 2.61 [1.44; 4.81], p < 0.002) in all models of the logical regression is statistically significant.