Abstract
Because of disagreement regarding the importance of maternal adrenal mineralocorticoid in gestational volume homeostasis and reproductive performance, we studied pregnant rats consuming standard or moderately sodium-restricted diets (22 or 2.2 mEq/100 gm), each subjected on gestational day 5 to SHAM surgery (SHAM) or adrenalectomy (ADNX), the latter combined with corticosterone replacement. Some animals were instrumented with chronic vascular catheters to measure plasma volume and mean arterial pressure (MAP) responses to captopril. We found that neither absolute plasma volume nor hematocrit was significantly altered by adrenalectomy in animals on either standard or sodium-restricted diets. However, Posmol, 9-10 mosmol/kg lower in SHAM pregnant than virgin controls, was 16-22 mosmol/kg below nonpregnant levels in ADNX dams. Despite this hypotonicity, plasma vasopressin (AVP) was not suppressed, suggesting hemodynamic stimulation of AVP secretion. Basal MAP was 105 ± 3 mm Hg and 100 ± 2 mm Hg in SHAM pregn...
Published Version
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