Abstract

HighlightsThe review presents the analysis of data on the physiological role and mechanisms of adiponectin in atherogenesis, and considers the prospects of transferring of existing knowledge into clinical practice. AbstractThe review is focused on the issues associated with the physiological role and signaling mechanisms of adiponectin. Data on the pathways and molecular mechanisms of adiponectin associated with atherogenesis was obtained using animal models with atherosclerosis, samples of atherosclerotic plaques and normal human arteries, cultured endothelial cells, macrophages and vascular smooth muscle. The perspectives of transferring of existing knowledge into clinical practice are discussed as well.

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