Robotic cell injection force control based on static PVDF sensor and Fuzzy-PID control method

Abstract

Cell injection procedure is very essential in the field of molecular biology, and the injection force affects the success rates very much. However, conventional methods of manipulating individual biological cell failed to make use of the injection force information. This article is intended to design a static micro-force sensor with a simple structure which employs the piezoelectric material PVDF (polyvinylidene fluoride) film as its sensing element to detect the micro-force during cells injection and to develop a close-loop control method to regulate the whole fore-tracking system. A Fuzzy-PID and an ordinary PD feedback control method are employed separately in this article to regulate the micro-force tracking system which is used to carry out automatic living-cell injection tests. Experimental results with different control methods are achieved. And the Fuzzy-PID and PVDF sensor based force control method is validated.