Abstract
Osteoporosis, the condition of decreased bone density resulting in bone porosity, brittleness, and a increased fracture risk is rising with aging. Current treatments slow-down bone loss but cannot increase bone formation and quality. Using osteoblasts–the bone forming cells–and RNAi libraries, we developed a high-content analysis approach which identified osteoblast modulators. Several among them are potential drug targets, to induce increase in bone formation thus efficiently combating osteoporosis.
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