RNA World Modeling: A Comparison of Two Complementary Approaches.

Abstract

Simple SummaryDespite years of dedicated research, scientists are still not sure what the first ”living” cell would have looked like. One of the most well-known hypotheses is the RNA world hypothesis, which assumes that, in the beginning, life relied on RNA molecules instead of DNA as information carriers and primitive enzymes. The population of such RNAs is made up of self-replicating molecules (replicases) that could make copies of themselves and parasite molecules that could only be copied by replicases. In this study, we further investigated the interplay between these hypothetical prebiotic RNA species, since it plays a crucial role in generating diversity and complexity in prebiotic molecular evolution. We compared two approaches that are commonly used to investigate such simple prebiotic systems, representing different modeling and observation scales—namely, microscopic and macroscopic. In both cases, we were able to obtain consistent results.The origin of life remains one of the major scientific questions in modern biology. Among many hypotheses aiming to explain how life on Earth started, RNA world is probably the most extensively studied. It assumes that, in the very beginning, RNA molecules served as both enzymes and as genetic information carriers. However, even if this is true, there are many questions that still need to be answered—for example, whether the population of such molecules could achieve stability and retain genetic information for many generations, which is necessary in order for evolution to start. In this paper, we try to answer this question based on the parasite–replicase model (RP model), which divides RNA molecules into enzymes (RNA replicases) capable of catalyzing replication and parasites that do not possess replicase activity but can be replicated by RNA replicases. We describe the aforementioned system using partial differential equations and, based on the analysis of the simulation, surmise general rules governing its evolution. We also compare this approach with one where the RP system is modeled and implemented using a multi-agent modeling technique. We show that approaching the description and analysis of the RP system from different perspectives (microscopic represented by MAS and macroscopic depicted by PDE) provides consistent results. Therefore, applying MAS does not lead to erroneous results and allows us to study more complex situations where many cases are concerned, which would not be possible through the PDE model.