Abstract
The subiculum of the hippocampal formation was sampled from 16 patients aged 8 months to 94 years at postmortem examination. An analysis of 960 single nerve cell bodies dissected from the subiculum showed a significant difference in the RNA content, the volume, and the RNA concentration measured at different ages. Both the neuronal RNA and the volume showed an adult value at 9 years of age and remained unchanged until 52 years of age. The mean RNA content and the volume was 44 pg and 5271 μm 3, respectively, during this period. A high neuronal RNA content was a characteristic feature of the subiculum in patients between the ages of 56 and 94 years. The onset of increased neuronal RNA coincided with an appearance of neurofibrillary tangles in the subiculum, implying that the substantial increase in RNA content may be related to subsequent synthesis of the neurofibrillary protein, which accumulates as neurofibrillary tangles.
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