Abstract
The effect of age on the neuronal RNA content and the volume of single nerve call bodies was examined in the hypoglossal nucleus. Human brain from 14 patients of ages ranging from 8 months to 94 years were obtained at postmortem examination. Both RNA content and cell volume showed adult levels at age 9 years. The RNA content remained unchanged until age 49 and the mean RNA content was 222.71 pg during this period. A decline in the RNA content followed with increasing age. The mean RNA content at age 92 was 116.80 pg, 48% less than that measured at age 49. Inspite of the prominent accumulation of lipofuscin pigments which accompanied increasing age, cell volume did not increase but rather remained unchanged up to the age of 80. The volume then decreased significantly in patients of more advanced age. Results from the present study have shown that the concomitant decrease in neuronal RNA is one of the significant aging changes in the hypoglossal nucleus.
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