Abstract
Infantile asthma, defined by the presence of three or more wheezing episodes before 2 years of age, is frequently considered as mainly being encouraged by small airways and passive tobacco smoke, and triggered by viral infections. IgE-dependent mechanisms may however also contribute to the pathophysiology of infantile asthma. First, allergenic sensitization is more frequently observed in asthmatic infants than in the whole population with the same age range. Second, some studies argue for a predisposing role of an early allergenic sensitization to the appearance of asthma in infants. When asthma is established, allergenic sensitization is associated with more acute episodes. Finally, the persistence of asthma from infancy to school age appears strongly influenced by personal or familial atopy.
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