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Abstract
The role of CXC chemokine receptors in tumors has been an increasingly researched focus in recent years. However, significant prognostic values of CXCR members in acute myeloid leukemia are yet to be explored profoundly. In this study, we firstly made an analysis of the relationship of CXCR family members and AML using samples from TCGA. Our results suggested that transcriptional expressions of CXCRs serve an important role in AML. CXCR transcript expressions, except CXCR1 expression, were significantly increased in AML. It displayed the expression pattern of CXCR members in different AML subtypes according to FAB classification. The correlations of CXCR transcript expression with different genotypes and karyotypes were also present. High CXCR2 expression was found to have a significantly worse prognosis compared with that of low CXCR2 expression, and CXCR2 was also found to be an independent prognostic factor. We also established a CXCR signature to identify high-risk subgroups of patients with AML. It was an independent prognostic factor and could become a powerful method to predict the survival rate of patients.
Highlights
Acute myelocytic leukemia (AML) is a malignant clonal disease of hematopoietic stem cells, which is characterized by a block of leukemic blasts in the bone marrow and other tissues [1]
We compared the transcript expressions of the CXC chemokine receptor (CXCR) in patients with AML with those of normal control subjects, using server Gene Expression Profiling Interactive Analysis server (GEPIA) [22]. 173 patients with AML from The Cancer Genome Atlas (TCGA) and 70 normal subjects from the Genotype-Tissue Expression (GTEx) portal were displayed on the website
The expression of the CXCR4 transcript was much higher in the AML group
Summary
Acute myelocytic leukemia (AML) is a malignant clonal disease of hematopoietic stem cells, which is characterized by a block of leukemic blasts in the bone marrow and other tissues [1]. Recent studies suggest that the interaction of the CXC chemokine receptor (CXCR) members and their ligands as well as the complex regulatory network of them take an effect on certain tumor-related processes [3] including activation, proliferation and invasion of leukemic cells [4]. CXCR1 and CXCR2 exhibit a high affinity toward a common ligand IL-8. This receptor-ligand interaction induces leukocyte chemotaxis, cell proliferation, and migration and is critical for inflammation and metastasis of tumors [6,7,8]
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