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Abstract
BackgroundCXCR4 chemokine receptors play an important role in leukemia proliferation, extramedullary migration, infiltration, adhesion, and resistance to chemotherapy drugs.MethodsThe CXCR4 expression by flow cytometry in 122 acute myeloid leukemia (AML) patients between 2010 and 2014 was analyzed.ResultsThe expression of CXCR4 in AML‐M4/M5 was found to be significantly higher than that of other subtypes according to both FAB subtype and WHO classification. The FLT3‐ITD mutant was significantly higher in high CXCR4 expression group (P = .0086). Our data also showed that CXCR4 expression was correlated with CD64 expression. Low CXCR4 expression on AML cells was associated with better prognosis, and the median overall survival (OS) for low CXCR4 expression patients was 318 days, compared with 206 days for patients with high CXCR4 expression (P = .045). Multivariate analysis revealed that CXCR4 expression, age, and extramedullary infiltration were independent prognostic factors.ConclusionsOur study demonstrated that CXCR4 expression in AML was an independent prognostic predictor for disease survival that could be rapidly and easily determined by flow cytometry at disease presentation.
Highlights
CXCR4, CXC chemokine receptor 4 (CD184), belonging to specific G protein‐coupled receptors, is the specific receptor of the chemokine matrix cell derivative‐1 (SDF‐1, CXCL12), and has a high affinity with the ligand.[1]
We examined for CXCR4 surface expression in acute myeloid leukemia (AML) blasts cells in 122 patient samples, and the expression level was 0.03%‐96.75%, which was consistent with the previous studies
Patients in each AML subtype were divided into high expression and low expression group according to the cut‐ point 3.84%
Summary
CXCR4, CXC chemokine receptor 4 (CD184), belonging to specific G protein‐coupled receptors, is the specific receptor of the chemokine matrix cell derivative‐1 (SDF‐1, CXCL12), and has a high affinity with the ligand.[1]. It is expressed in most tissues and organs in the body and participates in various physiological mechanisms. CXCR4 is expressed on the surface of hematopoietic stem cells, and expressed on leukemic blasts and leukemia cell lines. It plays an important role in leukemia proliferation, extramedullary migration, infiltration, adhesion, and resistance to chemotherapy drugs.[2-4]. We investigated the relationship between FLT3 gene and CXCR4 tested in the risk stratification model of AML
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