Abstract
With the development and wide use of assisted reproductive technology(ART), the number of children with ART is rapidly increasing worldwide. Consequently, the long-term safety issue of ART procedure has been a research hotspot in the related field. Several clinical and animal studies showed that ART individuals exhibited metabolic abnormalities including changes in glucose and lipid metabolism. The underlying mechanism of this phenomenon remains unclear, although some researchers believe that epigenetic and imprinting alterations caused by ART procedures and subsequent changes in the expression of metabolism-associated genes seems to be the most important reasons. This review will summarize the existing evidences of relationship between ART and metabolic abnormalities as well as its possible mechanisms. (Chin J Endocrinol Metab, 2016, 32: 791-794) Key words: Assisted reproductive technology; Metabolic disorder; Epigenetics
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