Abstract
fold and UC frequencies at the isthmic and fundal parts of the uterus were rated by 3 independent observers who were blinded for study design. Overall UC frequency was obtained by the average frequency between isthmic and fundal contractions and average ratings of observers. RESULTS: Median UC frequency (min-max) increased slightly but not significantly over the 3 observation points (baseline, IUI +15, and IVI +30): 3.2 (2.7-4.1), 3.3 (2.5-4.9), and 3.4 (2.4-4.8) UC/minute, respectively. Further, UC frequencywas not influenced significantly by semenvolume nor themagnitude of ovarian response. UC frequency was negatively correlated (Spearman test) with women’s ages at IUI +15 (r1⁄4-0.42, P< 0.04) and IVI +30 (r1⁄40.51, P< 0.009) but not at baseline (r1⁄4-0.20, NS). Yet, the % of increase of UC frequency over the 3 observation points was not related to women’s ages. Finally, pregnancy rates tended to be higher (30% vs. 15%) in patients showing R3.5 UC/minute (n1⁄413) than those with <3.5 UC/min (n1⁄413) at IVI +30. CONCLUSIONS: 1. Adding raw sperm containing prostaglandins just after conventional IUI results in a marginal, non significant increase in ultrasound-visualized UC frequency. 2. Mechanisms explaining the higher UC frequency in younger as compared to older patients, irrespective to COH results, remain to be elucidated. 3. Further adequately powered studies are warranted to verify the possible influence of UC frequency on IUI outcome.
Published Version
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