Abstract
The variability in the host immune response directed against dengue virus (DENV) has demonstrated the need to understand the immune response associated with protection in incident infection. The objective was to estimate the association between serostatus and the risk of incident DENV infection. We used a prospective study from 2014 to 2016 in the localities of Axochiapan and Tepalcingo, Morelos, Mexico. We recruited 966 participants, of which, according to their infection history registered were categorized in four groups. To accomplish the objectives of this study, we selected to 400 participants older than 5 years of age were followed for 2.5 years. Blood samples were taken every 6 months to measure serological status and infection by ELISA. In individuals with at least two previous infections the risk of new infection was lower compared to a seronegative group (hazard ratio adjusted 0.49, 95% CI 0.24–0.98), adjusted for age and locality. Therefore, individuals who have been exposed two times or more to a DENV infection have a lower risk of re-infection, thus showing the role of cross-immunity and its association with protection.
Highlights
Dengue is a viral disease transmitted by Aedes mosquitoes and is considered a public health problem w orldwide[1]
The endemic population were studied in two stages, the first stage comprising 2010 and 2011 and it was reported elsewhere[13,14].The recruitment for the second stage started in August 2014 and ended on November 2016, with a total of 7 follow-ups from 2011 to 2016
This work is notable for its long follow-up period, which allowed assessment of the seroconversion dynamics in these Mexican endemic populations
Summary
Dengue is a viral disease transmitted by Aedes mosquitoes and is considered a public health problem w orldwide[1]. In 2014, 40% of the world’s population was at risk of being infected, with the number estimated as between 50 and 100 million infections per year by any of the four serotypes (DENV-1 to DENV-4)[3]. The immunity generated in the population against several DENV serotypes and the evolution of the virus itself are considered factors influencing transmission, contributing to periodicity in the onset of dengue c ases[5]. In Peru, febrile cases reported in the postsecondary infection group compared to the primary and secondary infection groups dropped significantly by 93% for DENV-3, and 64% for DENV-4, showing that preexisting cross-reactive antibodies may decrease the risk of infection[10,11]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call