Risk of cerebral metastases for postoperative locally advanced non-small cell lung cancer

Abstract

8113 Background: Cerebral metastases contribute most to the failure of locally advanced non-small cell lung cancer (NSCLC) management. Implications of prophylactic cranial irradiation (PCI) for locally advanced NSCLC are still controversial. Our study assessed the risk factors of brain metastases in patients with postoperative locally advanced NSCLC. Implications for PCI are discussed. Methods: 233 patients treated with surgical resection for stage III-N2 NSCLC were retrospective analyzed. To find out the risk factors of brain metastases in patients with locally advanced NSCLC, and establish the mathematical model. Results: Median survival for the entire patient was 28 months. The overall survival at 1, 2, and 3 years was 84.3%, 56.9%, and 44.8%, respectively. Brain metastases rate for the entire patient was 38.1% (85/223). Brain metastases rate for patients with single mediastinal lymph-area metastases at 1, 2, and 3 years was 6.8%, 12.8%, and 16.6%, respectively. And brain metastases rate for patients w...