Risk of arterial hypertension development due to T393C gene polymorphism of α-subunit of G-protein

Abstract

According to foreign researchers, T393С gene polymorphism of α-subunit of the G-protein (rs7121) affects the sympathetic-adrenal system and the risk of hypertension. There are also data on the dependence of the manifestations of this polymorphism on the associated risk factors. However, these data are contradictory, which may be explained by ethnic differences in patients. In Ukraine there were no studies on this issue. We have studied 166 hypertensive patients and 90 healthy individuals. Determination of the polymorphism was performed by polymerase chain reaction with subsequent analysis of restriction fragments. The study found no statistically significant difference in the distribution of genotypes T393T, T393С, С393С in patients with hypertension and healthy subjects (p>0,05). The risk for hypertension in carriers of genotypes T393T + T393С relatively to С393С genotype was not significantly different (OR=1,44, 95% CI 0,74-2,80; p=0,283). During the analysis of the effect of smoking on the manifestations of T393С gene polymorphism α-subunit of the G-protein, no statistically significant difference were found (p>0,05). T393C gene polymorphism of α-subunit of G-protein did not affect the risk of hypertension.