Abstract
ObjectivePrevious studies have shown sex-specific differences in all-cause and CHD mortality in type 2 diabetes. We performed a systematic review and meta-analysis to provide a global picture of the estimated influence of type 2 diabetes on the risk of all-cause and CHD mortality in women vs men.MethodsWe systematically searched PubMed, EMBASE and Web of Science for studies published from their starting dates to Aug 7, 2018. The sex-specific hazard ratios (HRs) and their pooled ratio (women vs men) of all-cause and CHD mortality associated with type 2 diabetes were obtained through an inverse variance-weighted random-effects meta-analysis. Subgroup analyses were used to explore the potential sources of heterogeneity.ResultsThe 35 analyzed prospective cohort studies included 2 314 292 individuals, among whom 254 038 all-cause deaths occurred. The pooled women vs men ratio of the HRs for all-cause and CHD mortality were 1.17 (95% CI: 1.12–1.23, I2 = 81.6%) and 1.97 (95% CI: 1.49–2.61, I2 = 86.4%), respectively. The pooled estimate of the HR for all-cause mortality was approximately 1.30 in articles in which the duration of follow-up was longer than 10 years and 1.10 in articles in which the duration of follow-up was less than 10 years. The pooled HRs for all-cause mortality in patients with type 2 diabetes was 2.33 (95% CI: 2.02–2.69) in women and 1.91 (95% CI: 1.72–2.12) in men, compared with their healthy counterparts.ConclusionsThe effect of diabetes on all-cause and CHD mortality is approximately 17 and 97% greater, respectively, for women than for men.
Highlights
Diabetes is recognized as the world’s fastest growing chronic condition
Diabetes-related mortality was higher in women than men, and the effect of diabetes on all-cause and CHD mortality was 17 and 97% higher in women than men, respectively
In a recent collaborative meta-analysis, diabetes was associated with all-cause mortality, and the relative risks were 1.59 in men and 2.00 in women, respectively [68]
Summary
Diabetes is recognized as the world’s fastest growing chronic condition. Due to rapid increases in the prevalence of physical inactivity, overweight and obesity, the number of people with diabetes is projected to rise to 592 million by 2035 [1]. Type 2 diabetes (T2D) has attained the status of a global pandemic, with the total number of patients with T2D estimated at 425 million in 2015 [2]. Accumulating evidence documents T2D as an independent risk factor for all-cause mortality [3, 4, 5, 6]. The risk of all-cause mortality in persons with T2D is approximately doubled [7].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
