Risk factors related with congenital heart disease: a single center experience

Abstract

Aims: Many cases of congenital heart disease are multifactorial and result from a combination of genetic predisposition and an as-yet-to-be-determined environmental stimulus. The purpose of the study is to determine the patients who were diagnosed with CHD through echocardiography and to reveal the risk factors that may cause congenital heart anomalies in our center. Methods: The medical records of pediatric patients applied to our pediatric cardiology clinic between January 2010 –December 2017 were retrospectively reviewed. Results: 147 cases were diagnosed with CHD. 60 (52.6%) of the cases were female and 54 (47.4) were male. 77 of the 114 patients included in the study were acyanotic (67.5%) and 37 (32.5%) were cyanotic. Seventeen of the acyanotic patients had mixed CHD. The mean maternal gestational age was 28.2±5.78 years. 26 (22.8%) were born preterm. 17 (14.9 %) patients were born with low birth weight (under 2500 g). 8 (7%) patients were LGA (large for gestational age) (birth weight over 4000 g). Average birth weight was 2,98±740,8 gr. Consanguinity was found in the parents of 28 (24.5%) patients. There was a history of CHD in the relatives of 6 (5.2%) patients, siblings of 4 (3.5%) patients, and parents of 5 (4.3%) patients. Chromosomal abnormalities were found in 9 (7.9%) patients. Conclusion: Our study is a valuable contribution to the existing literature in that it showed that the frequency and distribution of congenital heart diseases have not changed in recent years, and its findings are compatible with the literature findings.