The relationship between the ABO blood group and chronic venous disease in deep vein thrombosis

Abstract

Aims: This study aims to investigate the relationship between the ABO blood group and chronic venous disease in terms of deep vein thrombosis (DVT). Methods: This study was planned as a retrospective case-control study in which 1031 patients were included between February 1, 2022, and July 1, 2022. After systematic sampling, the case group (88) and the control group (113) were analyzed in terms of blood groups. Then the patients were divided into 3 groups. group 1: patients with non-O blood group and chronic venous disease (CVD) (n=75), group 2: patients with non-O blood group and non-CVD (n=73), and group 3: patients with O blood group and CVD patients (n=28). It was analyzed whether there was a difference between these 3 groups and from which group and in what form. Results: The non-O blood group was significantly higher in the DVT group than the control group (p=0.001). There was no significant difference between A, B, and AB blood groups (p=0,21, p=0,51, p=0,08, respectively). When group 1, group 2, and group 3 were compared, a significant difference was found (p=0,006). In the posthoc analysis, no difference was found between group 1 and group 2 (p=0.99), a difference was found between group 3 and group 1 - group 2, and it was found to be lower (p=0.34, p=0.46, respectively). Conclusion: We found the non-O blood group was higher in the DVT group compared to the control group. We found that the non-O blood group alone was higher in patients with DVT than CVD alone. While non-O blood type and CVD are important risk factors for DVT, non-O blood type can increase the risk of DVT more than CVD. However, this finding needs to be discussed in future studies.