Risk factors of thyrotoxic cardiomyopathy

Abstract

A retrospective study covered 272 patients (mean age 54 years) admitted for different forms of toxic goiter concurrent with cardiac arrhythmias and/or sings with heart failure (HF), which was undertaken to explore risk factors of thyrotoxic cardiomyopathy (TTCM). Cardiac arrhythmias following the pattern of sinus tachycardia and/or supraventricular extrasystole without signs of HF were observed ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ. 2007. Т. 53, № 4. in S3 (19.5%) out of the 272 patients (a mild TTCM group - TTCM-1) whereas cardiac arrhythmias as atrial fibrillations and/or flutters and/or the devebpment of HF In the presence of thyrotoxicosis (TT) were detected in 219 (80.5%) of the 272 patients (a severe TTCM group - TTCM-2). Indices, such as admission age, an interval between TT detection and the initiation of treatment, a history of endocrine ophthalmopathy and cardiovascular pathology, were examined in the regression analysis considering the severe course of TTMC as a poor predictor. Comparison of the groups revealed statistically significant differences in such Indices, as the interval between TT identification to therapy (OR = 1.8; 95% CI = 1.06-3.13; p = 0.02) and the patients' age at the moment of admission (OR = 1.1, 95% CI = 1.02-1.15; p= 0.01).