Risk factors of intracranial infection by invasive intracranial pressure monitoring

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Objective To investigate the risk factors of intracranial infection in patients with invasive intracranial pressure monitoring. Methods In this study, 368 cases with craniocerebral injury (268 males and 100 females) were selected in Jiaxing Second Hospital from February 2016 to June 2017. They were hospitalized and were in accordance with the standard of diagnosis. The patients were divided into infection group (50 cases) and non-infection group (318 cases) according to whether the patient had intracranial infection or not. The differences in preoperative Glasgow Coma Scale, preoperative antibiotic use, invasive procedures, invasive time, ruptured intracranial aneurysms, combined skull base fractures and platelet counts were compared between the two groups. Logistic regression analysis was used to analyze the risk factors of intracranial infection by invasive intracranial pressure monitoring. Results Single factor analysis showed that comparing two groups, the differences were significant in the probe placement mode, probe indwelling time, cerebrospinal fluid leakage, extraventricular drainage, intracranial ruptured aneurysm, combined with skull base fracture, operation time and platelet count (χ2=5.530, 4.691, 11.387, 4.784, 19.473, 9.362, 17.173, 9.744, P all<0.05) . Logistic regression analysis showed that the operation time ≥ 4 h (OR=4.942, 95%CI: 1.657-4.169) , cerebrospinal fluid leakage (OR=2.976, 95%CI: 1.338-6.012) , intracranial ruptured aneurysm (OR=9.306, 95%CI: 6.142-11.932) , probe placement was performed under subdural drill or craniotomy (OR=0.085, 95%CI: 0.013-0.804) , extra ventricular drainage (OR=8.159, 95%CI: 2.102-29.734) were independent risk factors for intracranial infection by invasive intracranial pressure monitoring (P<0.05) . Conclusions It is suggested that the clinical indicators can be used to reduce the complications of invasive intracranial pressure monitoring by controlling the relevant indicators of invasive operation. Key words: Intracranial pressure; Infection; Risk factors