Risk factors of high-risk human papilloma virus infection in gynecological patients from Weifang People's Hospital

Abstract

Objective To investigate the prevalence of human papilloma virus (HPV) infections among gynecological patients and to identify the risk factors associated with high-risk HPV (HR-HPV) infection. Methods HPV DNA genotyping was performed in 391 HPV infected gynecological patients admitted in Weifang People's Hospital during January 2010 and December 2012. HPV negative patients (controls, n=356) were matched to HR-HPV positive patients (cases, n=356) with a 1∶1 ratio. All the participants took part in a questionnaire survey with 50 items, including demographic characteristics, pregnancy and reproductive history, living conditions, sexual behavior, family history, etc. Stepwise Logistic regression analysis was used to determine the risk factors of HR-HPV infection. Results Among 391 HPV positive patients, 318 (81.3%) were infected with one type of HR-HPV, 35 (9.0%) were infected with one type of low-risk HPV, and 38 (9.7%) were infected with mixed types. Logistic regression analysis showed that married women, age of sexual debut<20, multiple sexual partners, oral sex, commercial sexual activity, and vaginal douching more than once a week were risk factors of HR-HPV infection (OR=4.053, 1.861, 1.587, 2.420, 5.125 and 1.943, respectively, all P<0.01). Conclusions Unprotected sex may be associated with HR-HPV infection. Healthy sexual behavior should be encouraged, and the detection, prevention and control of HR-HPV infection should be strengthened. Key words: Human papilloma virus; Infection; Sexual behavior; Vaginal douching; Risk factors