Risk factors of contrast-induced nephropathy in patients with acute myocardial infarction treated with emergent percutaneous coronary intervention

Abstract

Objective To explore the risk factors of contrast-induced nephropathy (CIN)in patients with acute ST-segment elevation myocardial infarction(STEMI)treated with emergent percutaneous coronary intervention(PCI). Methods The clinical data of patients with STEMI treated by emergent PCI from January 2014 to February 2017 in Peking University People’s Hospital was reviewed. Exclusion criteria included contrast agent allergy, previous renal diseases, chronic renal failure, heart failure, tumor, acute infection, only one renal function test available during hospitalization and lacking essential medical records. Data of demographics, past medical history, general conditions at admission, laboratory findings, etc, were collected. Patients were divided into CIN group and non-CIN group. The univariate comparison analysis and Logistic regression analysis were performed to obtain the risk factors of CIN. Results A total of 236 patients were enrolled. The incidence of CIN was 10.2% (24/236). Univariable analysis demonstrated that the risk factors of CIN were age, diabetes mellitus, Killip grade ≥ 3 stage, serum uric acid (SUA) level at admission, blood glucose level at admission. Binary logistic regression analysis showed that SUA≥350 μmol/L at admission, blood glucos≥11 mmol/L at admission, age≥75 years were independent risk factors for CIN. Conclusion SUA≥350 μmol/L at admission, blood sugar≥11 mmol/L at admission, age≥75 years were independent risk factors of CIN in patients with STEMI treated with emergent PCI. Key words: Acute ST-segment elevation myocardial infarction; Contrast-induced nephropathy; Risk factors