Abstract
Purpose: Anastomotic leakage is one of the most common complications of esophagectomy, it serves as one of the main causes of postoperative death of esophageal cancer. It is of clinical significance to try to discover the risk factors that cause anastomotic leakage.Methods: This retrospective study was conducted on 1,257 consecutive esophageal cancer patients who underwent esophagectomy with intrathoracic anastomosis from January 2010 to December 2015 at a high volume cancer center. Multivariate Logistic Regression analysis, Spearman rank correlation analysis, Mann-Whitney U test and Kruskal-Wallis test were performed to identify the risk factors to the occurrence of anastomotic leakage and the length of hospital stay.Results: Intrathoracic anastomotic leakage occurred in 98 patients (7.8%). Older patients were more likely to develop anastomotic leakage. Patients with diabetes had a higher leakage rate. Intrathoracic anastomotic leakage, old age as well as comorbidities were associated with longer hospital stay.Conclusion: Our study suggested that old age and diabetes were risk factors to intrathoracic anastomotic leakage. In-hospital stay would be lengthened by intrathoracic anastomotic leakage, old age and comorbidities.
Highlights
IntroductionSurgical resection is still the main method for the treatment of early and middle stage of esophageal cancer
Esophageal cancer is a common malignant tumor of the alimentary tract [1]
Walther and others believed that cervical anastomosis was as safe as intrathoracic anastomosis, and there was no difference in the incidence of anastomotic leakage [12, 13]
Summary
Surgical resection is still the main method for the treatment of early and middle stage of esophageal cancer. Surgical techniques have made great progress, [2] radical resection of esophageal cancer remains very traumatic and complicated, and there are many complications in the perioperative period. Anastomotic leakage is one of the most common and serious complications of esophagectomy, it serves as one of the main causes of postoperative death after esophageal cancer operation [3,4,5]. Early diagnosis and early treatment of anastomotic leakage is of much importance to reduce the mortality after esophageal cancer operation. Few articles focused on the influential factors of intrathoracic anastomotic leakage in esophageal cancer patients have been reported
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