Abstract
Background: One of the major causes of death in heart transplantation (OHT) is post transplant malignancy. Our objective is to identify risk factors for malignancy after OHT. Methods: Adult primary OHT recipients reported to the Organ Procurement and Transplantation Network/United Network for Organ Sharing from 2000-2012 were included (n=46,113). Cancer-free survival time was calculated. Multivariate Cox regression analysis was performed to characterize risk factors for post-OHT malignancy. Results: Post transplant malignancy was reported at least once in 7,427 recipients (16.1%). Median time to malignancy was 4.8 years (interquartile range: 1.4-9.0). The distribution of cancers included: skin cancer (9.2%), solid tumors (7.2%), and post transplant lymphoproliferative disease (1.6%). Pre-transplant malignancy, age 40-59 years, age ≥60 years, male gender, and white race were associated with an increased risk of post transplant malignancy (HR=1.76, 3.09, 5.44, 1.53, 2.39; all P<0.001, respectively).Figure: No Caption available.Conclusions: Our study showed that pre-transplant malignancy, older age, male recipient, and white race were associated with an increased risk of post-OHT malignancy.
Published Version
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