Abstract
Introduction 
 The pandemic, in terms of incidence, mortality and speed of expansion, is heterogeneous, even between regions of the same country, finding differences in its clinical presentation, severity and lethality; For this reason, the research aims to: know the risk factors associated with mortality in adult patients with COVID 19.
 Material and methods
 Retrospective cohort study included hospitalized patients, older than 18 years, diagnosed with Covid-19 through RT-PCR test. Data collected from the electronic file and analyzed to detect differences between survivors and non-survivors, using Student's t-test and Chi-square or Fisher's exact test. The relative risk was calculated with a 95% Confidence Interval (with statistical significance p <0.05.
 Results
 247 patients were studied. With a lethality of 50.20%. Arterial hypertension was the most frequent comorbidity. The oxygen supply with an invasive device was associated with a high risk of death. Tracheostomy is a high factor (p <0.001). With a statistical difference in favor of the early one. The mask and the nasal tips showed a protective effect (p <0.05). The most frequent symptoms were dyspnea, fever and cough without statistical difference. SatO2 at admission did show significance between both groups.
 Conclusion
 There is a difference between the risk factors in both groups. A peripheral SatO2 of <90% at admission and the determination of PNC and D-DIME warrant close monitoring to avoid severe complications.
Highlights
The pandemic, in terms of incidence, mortality, speed of expansion, the clinical presentation of a disease, and severity, is heterogeneous between regions of the same country
Some regions in the world are showing a downward trend in new cases; Europe is the largest contributor of deaths in recent weeks, and the Americas reported an increase in new cases of deaths, which is why this disease is currently considered to have the highest proportion of accumulated cases and deaths [2]
2.42 2.01 (0.91 to 1.90) 0.10 (0.65 to 1.06) 0.14 (0.86 to 1.42) 0.45 (0.67 to 1.26) 0.62 (0.90 to 1.54) 0.24 (0.81 to 1.47) 0.54 (0.57 to 1.24) 0.36 (0.66 to 1.38) 0.83 (0.62 to 1.26) 0.48 (0.59 to 1.27) 0.46 (0.55 to 1.44) 0.64 (0.65 to 1.74) 0.80 (0.62 to 1.89) 0.76 (0.35 to 2.01) 0.69 (0.59 to 2.19) 0.70 (0.26 to 2.33) 0.64 (0.13 to 3.29) 0.55 (1.77 to 2.28) 0.08 n: number of patentes %: percentages Source: Epidemiology, Regional Hospital of High Specialty "Bicentenario 2010", Pediatrics Division, Ciudad Victoria, Tamaulipas, Mexico. In this COVID-19 study, the behavior of the severe acute respiratory syndrome (SARS)-CoV-2 coronavirus infection was compared in patients who did not survive against survivors
Summary
The pandemic, in terms of incidence, mortality, speed of expansion, the clinical presentation of a disease, and severity, is heterogeneous between regions of the same country. For this reason, the research aims to establish the risk factors associated with mortality in adult patients with COVID-19 in northeast Mexico. The most frequent symptoms were dyspnea, fever, and cough without statistical difference among the study groups (patients who were discharged alive from the hospital and those deceased). Risk factors could predict mortality in patients with COVID-19. For February 28 of the same year, the INDRE (Institute of Epidemiological Diagnosis and Reference) confirmed the first case of COVID-19 in Mexico. Since there is currently no specific treatment, the prevention and control measures recommended by the World Health Organization (WHO) should be continued [3]
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