Risk factors for active tuberculosis in human immunodeficiency virus-infected individuals

Abstract

Context: Tuberculosis (TB) has become the most common opportunistic infection among individuals with human immunodeficiency virus (HIV) infection worldwide and continues to be a major killer resulting in 0.4 million deaths every year. While some of the risk factors for developing TB in HIV-infected individuals are known, identifying other risk factors will help in screening strategies to pick out those at higher risk for closer follow-up. Aims: The aim of this study was to identify the risk factors related to the development of active TB in HIV-infected individuals. Settings and Design: This case–control study among the HIV-infected individuals was carried out at a HIV clinic in a large tertiary care hospital in South India. Methods: HIV-infected individuals >18 years of age with confirmed TB were chosen as cases. For each case, two age- and sex-matched controls, diagnosed to have HIV infection without active TB or history of TB, were included. The potential risk factors for the development of active TB were evaluated using the odds ratios (ORs) and logistic regression analysis. Results: A total of 150 patients, 50 cases (mean age: 39.3 ± 7.2 years) and 100 controls (mean age: 40.2 ± 7.1 years) were included. On univariate analysis, smoking (OR 8.14, 95% confidence interval [CI]: 3.13–21.21; P