Risk factors contributing to postoperative severe hypoproteinemia in patients with lung cancer

Abstract

Objective To detect risk factors contributing to severe hypoproteinemia (serum albumin <25 g/L) in postoperative patients with lung cancer. Methods The clinical data of 200 patients with lung cancer who received surgical treatment in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to November 2012 were retrospectively analyzed.The single factor analysis was carried out with χ2 test, and the logistic regression equation was used to analyze the multiple factors.Correlation factors of postoperative severe hypoproteinemia of lung cancer were analyzed by the receiver operator characteristic curve. Results Sixty-four patients (32.0%)were complicated with postoperative hypoproteinemia.Univariate statistical analysis showed that age, size of tumor, operative method, amount of thoracic cavity drainage, duration of fever, the highest body temperature, preoperative hypoproteinemia (serum albumin <34 g/L), and lymph node dissection were correlated with postoperative severe hypoproteinemia (all P<0.05). Multivariate logistic regression analysis showed that amount of thoracic cavity drainage, duration of fever, the highest body temperature, preoperative severe hypoproteinemia, lymph node dissection were the independent risk factors of postoperative severe hypoproteinemia (χ2=114.679, P=0.000). There was a significant difference in the incidence of postoperative severe hypoproteinemia among patients with different risk stratification (χ2=36.280, P<0.05). Conclusions The risk factors of postoperative severe hypoproteinemia in patients with lung cancer are postoperative amount of thoracic cavity drainage >1 000 ml, duration of fever > three days, the highest temperature ≥38.5 ℃, preoperative serum albumin level <34 g/L, lymph node dissection. Key words: Lung cancer; Postoperative; Hypoproteinemia; Risk factors