RISK FACTORS ASSOCIATED WITH INCREASED MORTALITY IN SEPTIC PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT/ FATORES DE RISCO ASSOCIADOS AO AUMENTO DA MORTALIDADE EM PACIENTES SÉPTICOS ADMITIDOS NA UNIDADE DE TERAPIA INTENSIVA

Abstract

Sepsis is a potentially fatal clinical syndrome characterized by an abnormal response to infection associated with organic dysfunction. It is a relevant cause of admission to intensive care units (ICUs) and related to increased morbidity and mortality rates. This study aimed to evaluate the epidemiological profile of adult ICU patients of Lauro Wanderley University Hospital (HULW) in the municipality of João Pessoa (PB) to determine the risk factors associated with increased mortality in patients with sepsis. This retrospective and observational methodological study evaluated the epidemiological profile and characteristics of patients with sepsis, aiming to analyze the risk factors related to increased mortality. The mortality risk analysis was performed in two parts. The first was made from Pearson’s chi-square test to determine the association between categorical variables. Thus, only those variables with p values < 0.05 were included in the final logistic regression model to neutralize the effects of the confounding variables, for which values of p < 0.05 were considered significant. This study’s findings suggest that septic shock and IMV and CVC use are the factors that deserve greater attention in patients with sepsis. However, among them, IMV is the main risk factor for death in ICU patients with sepsis. Variables such as sex, age, and comorbidities did not inflate the death rate for the patients studied.