Abstract
Objective To elucidate the risk factors and surgical outcome of secondary epilepsy arising from intracranial meningioma. Methods A retrospective study was conducted on the clinical data of 267 patients with intracranial meningioma admitted to Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University from January 2015 to December 2015. All those patients underwent surgical operations. The seizure outcome was followed up through outpatient visits or telephone post operation. Univariate analysis and Cox proportional hazards model were applied to identify the predictive factors for epileptic seizures in patients with supratentorial meningioma. Results In this series, the incidence of epileptic seizures arising from meningioma was 17.2% (46/267). Univariate analysis demonstrated 4 predictive factors for preoperative epilepsy: tumor location (perirolandic area) (P<0.01), male patients (P=0.01), young people (less than 45 years old) (P<0.01) and hydrocephalus (P<0.01). Two independent predictors were confirmed by multivariate analysis: tumor location (perirolandic area) (HR=2.21, 95%CI: 1.23~3.97, P=0.008) and young people (HR=2.03, 95%CI: 1.11~3.68, P=0.021). A total of 213 patients were successfully followed up for an average duration of 24±13 months. Also, the status seizure free was reported in 80.4% (37/46) of the meningioma patients with preoperative seizures. Conclusions Epileptic seizures are common in patients with meningiomas and more likely to be observed in those with tumors located in motor-related areas and young people. Tumor resection could result in favorable seizure outcome. Key words: Meningioma; Epilepsy; Risk factors; Prognosis; Motor cortex
Published Version
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