Abstract
IntroductionHuman papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) genotypes largely responsible. The objective is to ascertain the distribution of oncogenic strains of human papilloma virus genotypes and predisposing risk factors in women presenting for cervical cancer screening in Nigeria.MethodsA cross-sectional study of 80 women who presented for cervical cancer screening. The biodata of the participants, the presence of risk factors to HPV were recorded and hrHPV were identified using PCR technique. The information obtained was processed using the SPSS version 20 software. Results were presented in tables, test of significance and association done using student's t-test and Odds ratio, with P value < 0.05 as significant.ResultsThe age range of patients was 19-62 years with prevalence of hrHPV of 10%. HrHPV are more in patients with more than one life time sexual partner (OR 1.26,95%CI 0.13-29.99), multiple sexual partners (OR 1.55, 95% CI 0.28-8.70), early coitarche (OR 1.57, 95% CI 0.14-15.00) and previous STI (OR 150, 95%CI 9.53-1979. 62). Four hrHPV genotypes: 16, 18, 31 and 35 were detected.ConclusionHPV genotype 18 was predominant in Port Harcourt, Nigeria. High risk sexual behaviours are associated with acquisition of hrHPV.
Highlights
Human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk human papilloma virus (HPV)(hrHPV) genotypes largely responsible
It is based on this premise that this study seeks to determine the predominant high risk HPV genotypes in the region; in addition to elucidating the risk factors associated with this infection so as to facilitate measures of reducing the scourge of cervical cancer in the populace, which has been linked to human papilloma virus infection
Eight women out of the 80 women who participated in the study were positive for the oncogenic strains of human papilloma virus giving a prevalence of 10%
Summary
Human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) genotypes largely responsible. The objective is to ascertain the distribution of oncogenic strains of human papilloma virus genotypes and predisposing risk factors in women presenting for cervical cancer screening in Nigeria. About 99% of cases of cervical cancer have been associated with human papilloma virus infection which is a sexually transmitted disease [2]. It is based on this premise that this study seeks to determine the predominant high risk HPV genotypes in the region; in addition to elucidating the risk factors associated with this infection so as to facilitate measures of reducing the scourge of cervical cancer in the populace, which has been linked to human papilloma virus infection
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