Abstract
INTRODUCTION: human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) genotypes largely responsible. The objective is to ascertain the distribution of oncogenic strains of human papilloma virus genotypes and predisposing risk factors in women presenting for cervical cancer screening in Nigeria. METHODS: a cross-sectional study of 80 women who presented for cervical cancer screening. The biodata of the participants, the presence of risk factors to HPV were recorded and hrHPV were identified using PCR technique. The information obtained was processed using the SPSS version 20 software. Results were presented in tables, test of significance and association done using student's t-test and Odds ratio with P value < 0.05 as significant. RESULTS: the age range of patients was 19-62 years with prevalence of hrHPV of 10%. HrHPV are more in patients with more than one life time sexual partner (OR 1.26,95%CI 0.13-29.99), multiple sexual partners (OR 1.55, 95% CI 0.28-8.70), early coitarche (OR 1.57, 95% CI 0.14-15.00) and previous STI (OR 150, 95%CI 9.53-1979. 62). Four hrHPV genotypes: 16, 18, 31 and 35 were detected. CONCLUSION: HPV genotype 18 was predominant in Port Harcourt, Nigeria. High risk sexual behaviours are associated with acquisition of hrHPV.
Highlights
Human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk human papilloma virus (HPV)(hrHPV) serotypes largely responsible
HrHPV are more in patients with more than one life time sexual partner, multiple sexual partners, early coitarche and previous STI
Highrisk sexual behaviours are associated with acquisition of hrHPV
Summary
Human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) serotypes largely responsible. Every two minutes, a woman dies of cervical cancer and it is the leading cause of cancer deaths with women in developing countries accounting for the 85% of this deaths [2]. About 99% of cases of cervical cancer have been associated with human papilloma virus infection which is a sexually transmitted disease [2]. About 80% of women will acquire an HPV infection in their lifetime and HPV serotypes 16, 18, 45, 31 and 33 are the most common types associated with cervical cancer worldwide [2,3]. About six percent of cervical cancers cases have been associated with are associated with multiple HPV infections [2]
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