Risk factors analysis of persistent frequency after transurethral resection of the prostate

Abstract

Objective To discuss the risk of factors influencing persistent frequency after transurethral resection of the prostate (TURP). Methods The clinical data of 119 post-TURP patients treated from January 2014 to June 2015 was retrospectively analyzed. The age was (72.1±2.3)years old. There were 15 cases with hypertension, 23 cases with diabetes and 6 cases with heart disease. The preoperative IPSS score of 119 cases was (22.1±5.9) points, with (10.2±1.8) points in urinary storage period and (11.8±4.7) points in urination period. Urination frequency was (10.8±2.6) times per day and there were (3.8±0.8) times of nocturnal urination. B-ultrasound: residual urine volume was (38.1±9.1) ml and prostate volume was (34.1±4.2) ml. Preoperative maximum urine flow rate was (8.8±3.9) ml/s. The detrusor pressure at maximum urinary flow rate was (43.9±14.1) cm H2O (1 cmH2O = 0.098 kPa), maximum detrusor pressure was (99.7±12.2) cmH2O and effective bladder volume was (217.5±14.8) ml. Contraction of bladder weakened in 40 cases (33.6%) and 36 cases (30.2%) had detrusor overactivity. According to whether continuous urinary frequency was developed, the patients were divided into frequency-positive group and frequency-negative group. The differences between the patients in two groups were compared and univariate analysis was performed. A multivariate logistic regression was performed on statistically significant indicators. Results Among the 119 patients, 21 were frequency-positive and 98 were frequency-negative. Univariate analysis showed that age, IPSS score, preoperative urinary storage score, detrusor pressure at maximum urinary flow rate, maximum detrusor pressure, effective bladder volume, contraction decrease of bladder, preoperative detrusor activity were important indicators affecting the condition of postoperative urinary frequency (all P<0.05). Multivariate analysis showed that old age (OR=3.842, P=0.021), high total IPSS score (OR=5.109, P=0.011), low maximum detrusor pressure (OR=3.477, P=0.039), low effective volume of bladder (OR=4.051, P=0.017) and detrusor overactivity (OR=3.662, P=0.025) were independent risk factors for urinary frequency after TURP. Conclusions The age, the high IPSS score before operation, low maximal detrusor pressure, low effective bladder capacity and the bladder detrusor activity could be independent predictive factors of persistent frequency after TURP. Key words: Transurethral resection of prostate; Persistent frequency; Risk factors