Abstract
Introduction: The number of cleft lips or palatal cases is still very high in Indonesia, the growth of cleft lips or the palatal cases was 1: 700. This prevalence varied for each region in Indonesia. The cleft condition brings with it complications of mastication, pronunciation, and aesthetics function. The condition and composition of saliva in children affect the condition of dental caries, including protein statherin, histatin -1, and calcium minerals. The purpose of this study was to analyze the children's saliva of the cleft lip/palatal against the risk of caries.
 Material and Method: This study used an Observational Analytic method with a Post Test Only Control Group Design. Saliva samples were taken by the pipetting method, saliva samples were taken from 20 children with cleft lip with or without palate and 20 normal children, aged 3-17 years, good general health. Analysis levels of Statherin, Histatin-1, and Calcium minerals using the ELISA Method. Statistical analyze using ANOVA. 
 Result and Disscusion: The results showed that the average level of statherin for children with a cleft lip was 0.65 µg / ml, whereas normal children were 1.1 µg / ml, the results of the analysis of histatin-1 salivary protein showed an average of 0.86 ± 0.50 at cleft children and 1.01 ± 0.71 for normal children, mean calcium levels in saliva for cleft children is 1.09 ± 0.09 mmol / L and normal children were 1.34 ± 0.13 mmol / L. ANOVA analysis for the three salivary components were found to be p = 0.001, which means that there were significant differences between the average levels of statherin, histatin-1, and calcium in cleft lips children with or without cleft palate and normal children.
 Conclusion : There were differences in levels of Statherin, Histatin-1, and Calcium saliva in cleft lips children with or without cleft palate non-syndromic and normal children. Then cleft lips/palate tend to be caries risk rather than a normal child.
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