Abstract
Risk assessment of indeterminate lung nodule characterization by a novel plasma-protein multiplexed assay in current smokers: Results of a clinical experience program
Highlights
Lung nodule management decisions are based on the diagnostic yield of available tests to estimate the probability that a nodule is malignant
Using the VA Clinical Factors model, one sample had a low pre-test probability of cancer, 42 samples were calculated as having an intermediate risk pre-test probability of malignancy, and 11 samples were calculated as having a high risk pre-test probability of malignancy
We report on the results of a clinical experience program
Summary
Lung nodule management decisions are based on the diagnostic yield of available tests to estimate the probability that a nodule is malignant. Clinical acumen and/or validated probability calculators are currently used to guide the individualized management of the patients’ risk their nodule is malignant. These estimated risks can be grouped into low, intermediate, or high probability categories that relate to pathways for recommended management (Figure 1) [1]. Very small solid lung nodules have a low probability of malignancy and there are currently no tests available for these nodules with a useful diagnostic yield. To reduce overdiagnosis and overtreatment of non-cancerous pulmonary nodules found on chest imaging, an accurate non-invasive and administered test is needed to assist in the detection and diagnosis of cancers in a cost-effective manner at an early stage, when curative interventions are still possible
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